Experimental evaluation of a tissue adhesive as an agent for the treatment of aneurysms and arteriovenous anomalies

✓ Studies were performed on adult mongrel dogs to evaluate the possibility of occluding saccular aneurysms and arteriovenous (AV) anomalies with an intravascular injection of the tissue adhesive isobutyl-2-cyanoacrylate (IBC). Twelve normal canine renal arteries, four surgically constructed AV fistulas, and six surgically constructed vein pouch aneurysms were occluded by the injection of IBC through a fluoroscopically positioned intra-arterial catheter. The IBC was also directly injected into 25 surgically constructed vein pouch aneurysms. Angiography performed immediately after injection and up to 3 months following treatment revealed persistent occlusion of the renal arteries, arteriovenous fistulas, and aneurysms. Tissue reaction to the IBC was mild and confined to the intima in these experiments. Further investigation of this procedure for the treatment of aneurysms and arteriovenous anomalies by either a stereotaxic or selective catheterization technique is suggested.