Design principles of adhesive hydrogels for biomedical application

Adhesive hydrogels have great potential for application in the biomedical field. Currently, for clinical applications, adhesive hydrogels need to have the following characteristics: good biocompatibility, strong tissue adhesion, highly adaptable tissue specificity and multifunctionality, which are also included in the design principles of current adhesive hydrogels. When targeting different types of diseases in different tissues, adhesive hydrogels need different degrees of attention to these four key properties according to the characteristics of the pathological microenvironment of the tissue. In this regard, this article reviews the clinical disease characteristics of different tissues, and correspondingly introduces the considerations in the design process of adhesive hydrogels for this type of disease and application, in order to deepen the understanding of the design principles of adhesive hydrogels in biomedical applications.