PD27-06 THE ASSOCIATION BETWEEN ALTERATION IN GUT MICROBIOME AND OVERACTIVE BLADDER

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology (PD27)1 Sep 2021PD27-06 THE ASSOCIATION BETWEEN ALTERATION IN GUT MICROBIOME AND OVERACTIVE BLADDER Teppei Okamoto, Atsushi Imai, Shingo Hatakeyama, Hayato Yamamoto, Tohru Yoneyama, Kazuyuki Mori, Takahiro Yoneyama, Yasuhiro Hashimoto, Shigeyuki Nakaji, and Chikara Ohyama Teppei OkamotoTeppei Okamoto More articles by this author , Atsushi ImaiAtsushi Imai More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Hayato YamamotoHayato Yamamoto More articles by this author , Tohru YoneyamaTohru Yoneyama More articles by this author , Kazuyuki MoriKazuyuki Mori More articles by this author , Takahiro YoneyamaTakahiro Yoneyama More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , Shigeyuki NakajiShigeyuki Nakaji More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002020.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Overactive bladder (OAB) is part of lower urinary tract symptoms (LUTS) and prevalent among middle-aged and older individuals. Specific alterations of the microbiome (dysbiosis) in urine have been reported in association with lower urinary tract symptoms (LUTS). However, the association of LUTS with gut microbiome has not yet been fully understood. We investigated associations between the gut microbiome and OAB with daily urinary urgency. METHODS: We cross-sectionally surveyed 1113 individuals who participated in the Iwaki Health Promotion Project in Japan. We defined OAB as urinary urgency at least once per week and an Overactive Bladder Symptom Score (OABSS) of ≥3. OAB with urinary urgency at least once a day was defined as daily urgency. The gut microbiomes were assessed by next-generation sequencing of 16S rRNA genes extracted from fecal samples. The participants were divided into two groups: OAB-daily urgency and non-OAB. Cases were selected for inclusion on the basis of 1:1 propensity score matching; we assigned 58 individuals to each group (23 male and 35 female) for our analysis. RESULTS: Individuals reporting OAB with daily urinary urgency demonstrated a lower bacterial diversity between individuals (Bray–Curtis distance 0.48 vs. 0.53, p<0.001); the results cluster differently in the non-OAB groups. The relative abundance of genus Bifidobacterium (genus which may play critical beneficial roles and have been used as probiotics) was significantly lower among those reporting daily urgency (2.41% vs. 4.23%, p=0.014). By contrast, the relative abundance of genus Faecalibacterium (reduced genus in disorders including irritable bowel syndrome, inflammatory bowel disease, and depression) (9.25% vs. 6.26%, p=0.006) was significantly higher in this group. CONCLUSIONS: We observed significant differences in gut microbial contents and specific bacterial genera in association with OAB with daily urgency. Further study will be necessary to assess causal relationships between the gut microbiome and OAB. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e445-e446 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Teppei Okamoto More articles by this author Atsushi Imai More articles by this author Shingo Hatakeyama More articles by this author Hayato Yamamoto More articles by this author Tohru Yoneyama More articles by this author Kazuyuki Mori More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Shigeyuki Nakaji More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement Loading ...