Advances of Oncolytic Vaccinia Virus for the Treatment of Tumor

Oncolytic virus can selectively kill cancer cells and normal cells are generally left intact.Nearly 10 kinds of oncolytic viruses have been developed in recent years.Vaccinia virus has an enormous use in humans for the eradication of smallpox.In addition,vaccinia virus replicates rapidly,has highly immunogenic and well-known side effect.Genetic modified vaccinia virus can selectively replicate and lyse tumor cells.The report ed oncolytic vaccinia virus researches mainly based on the backbone of Western Reverse strain,Wyeth strain,List er strain and Copenhagen strain.There is no related report about Tian-Tan strain.