[D-Penicillamine effect on collagen synthesis and structural maintenance Red Sirius staining with polarized-light examination. The value of this staining in cases of collagen diseases (author's transl)].

A severe systemic sclerodermia has been treated by D-Penicillamine. A pathological study before and after treatment showed important changes of the collagen structure. The soluble or foetal collagen fraction is enhanced. By the Red-Sirius staining with polarized light examination of the bundles of foetal collagen are green and bright. Then, this staining appears as a marker of collagen structures.