化学
代谢组学
质谱法
质谱成像
毛细管电泳-质谱法
解吸电喷雾电离
电喷雾电离
马尔迪成像
色谱法
基质辅助激光解吸/电离
代谢物
电离
分析化学(期刊)
解吸
化学电离
离子
生物化学
有机化学
吸附
作者
Siqi Gao,Jin‐Hui Zhao,Yue Guan,Ying‐Shu Tang,Ying Li,Liyan Liu
摘要
Abstract Mass spectrometry imaging (MSI) is a powerful label‐free analysis technique that can provide simultaneous spatial distribution of multiple compounds in a single experiment. By combining the sensitive and rapid screening of high‐throughput MS with spatial chemical information, metabolite analysis and morphological characteristics are presented in a single image. MSI can be used for qualitative and quantitative analysis of metabolic profiles and it can provide visual analysis of spatial distribution information of complex biological and microbial systems. Matrix‐assisted laser desorption ionization, laser ablation electrospray ionization and desorption electrospray ionization are commonly used in MSI. Here, we summarize and compare these three technologies, as well as the applications and prospects of MSI in metabolomics.
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