Platelet-rich Plasma Injection for Enterocutaneous Fistula: A Case Report

Introduction. An ECF is an abnormal communication between the small or large bowel and the skin. PRP provides a variety of bioactive factors to promote wound healing. This case report details the use of PRP in the management of ECF. Case Report. A 52-year-old male with a history of duodenal perforation and duodenal fistula repair surgery presented with intermittent discharge of light-yellow material from the drainage tube removal site. Symptoms had not improved after 7 months of dressing changes. The patient had no signs or symptoms of generalized sepsis or peritonitis. A diagnosis of ECF was made based on the symptoms and physical examination. One application of PRP was injected into the fistula, and the fistula closed within 2 weeks. At 6-month follow-up, the patient had neither fistula recurrence nor abdominal pain. Conclusions. The findings in this case report suggest that PRP can be used in the management of ECF in patients with no signs and symptoms of generalized sepsis or peritonitis to promote fistula closure and decrease time to healing.