Erythropoietin is an important drug for the treatment of anemia in hemodialysis patients. But there were many patients with erythropoietin-hyporesponsive. Roxadustat has been shown effective in treating patients with anemia due to chronic kidney disease. However, the efficacy and safety of roxadustat in hemodialysis patients with erythropoietin-hyporesponsive anemia remains unclear.