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 Amyloid-beta and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons |
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Corpus ID: 4659453 Keifer P. Walsh, L. Minamide, Sarah J. Kane, Alisa E. Shaw, David R. Brown, B. Pulford, M. Zabel, J. Lambeth, Thomas B. Kuhn, J. Bamburg less Medicine, Biology TLDR It is shown that proinflammatory cytokines (TNF a, IL-1 b, IL-6) also induce rods at the same rate and within the same neuronal population as A b d/t. Abstract Neurites of neurons under acute or chronic stress form bundles of filaments (rods) containing 1:1 cofilin:actin, which impair transport and synaptic function. Rods contain disulfide cross-linked cofilin and are induced by treatments resulting in oxidative stress. Rods form rapidly (5–30 min) in . 80% of cultured hippocampal or cortical neurons treated with excitotoxic levels of glutamate or energy depleted (hypoxia/ischemia or mitochondrial inhibitors). In contrast, slow |
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