化学
亚硝基
组合化学
级联
功能群
氧化磷酸化
多米诺骨牌
赫克反应
级联反应
阿立哌唑
有机化学
钯
催化作用
生物化学
计算机科学
程序设计语言
聚合物
精神分裂症(面向对象编程)
色谱法
作者
Zhongyuan Li,Xiaojian Chen,Hulin Zhong,Yuankun Lin,Yang Gao,Yuan Liu,Qian Chen,Yanping Huo,Xianwei Li
摘要
The exploration of green C-H oxidation for the rapid construction of functional molecules, remains a permanent goal in synthetic chemistry. Herein, a traceless N-nitroso enabled oxidative Heck and amidation cascade was realized, leading to quinolinones that feature green oxidation and great functional group tolerance. The expedient construction of quinolinone containing pharmaceuticals including Flucarbril, Clostamide and Aripiprazole was achieved in a concise and environmentally friendly manner.
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