Which cognitive behavioral therapy delivery formats work for depressive symptoms in dementia caregivers? — A systematic review and network meta-analysis of randomized controlled trials

Cognitive behavioral therapy (CBT) has been shown to be effective to improve depressive symptoms by changing their cognitive processes and concepts for dementia caregivers (DCs). However, whether CBT can be effectively delivered in individual, group, telephone-administered, internet, combine formats remains unclear. We aimed to examine the most effective delivery format for CBT via a network meta-analysis (NMA). An exhaustive literature search was conducted based on Pubmed, Embase, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure database, Chinese Biomedical Literature Database, Wan Fang database, and unpublished data. RCTs were identified from their inception to January 15, 2022. We conducted pairwise and NMA to evaluate the relative effectiveness and rank probability (rank P-score) for different CBT delivery formats. A series of analyses and assessments, such as the risk of bias, and GRADE were performed concurrently. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were used for abstracting data. A total of 37 studies were included in our analysis based on a series of rigorous screenings, which comprised 4191 DCs. Compared with controls, internet (SMD = −1.33, confidence interval (CI): −2.18, −0.66, GRADE low), telephone (SMD = −1.29, CI: −1.89, −0.61, GRADE moderate), and individual (SMD = −1.04, CI: −2.01, −0.07, GRADE very low) showed the largest improvement on depressive symptoms, whereas the group and combine delivery formats were not effective. Notably, there were no statistically significant differences between these five delivery formats: internet, telephone, individual, group, and combine. Sensitivity analyses supported the overall findings. Our results suggested that internet, telephone, individual CBT delivery formats were effective for reducing depressive symptoms in DCs. Given the limitations of the NMA approach and the number of included studies, the result should be cautiously interpreted. Further RCTs with respect to the CBT based on different delivery formats' effectiveness are needed.