四分位间距
医学
银屑病性关节炎
银屑病
生物标志物
内科学
优势比
置信区间
关节炎
胃肠病学
免疫学
生物化学
化学
作者
Fatima Abji,Remy Pollock,Kun Liang,Vinod Chandran,Dafna D. Gladman
摘要
Objective Biomarkers that can predict the development of psoriatic arthritis (PsA) in patients with psoriasis would be useful in clinical practice. The aim of this study was to assess whether CXCL10 could be a predictive biomarker of PsA prior to its onset. Methods Psoriasis patients without arthritis were followed up prospectively and assessed annually for development of PsA by a rheumatologist. Patients in whom PsA developed were designated as converters, while those in whom PsA did not develop were termed nonconverters. Baseline serum concentrations of CXCL10 were measured by Luminex assay in 46 converters and 45 nonconverters. Results The level of CXCL10 was significantly higher in converters (median 493 pg/ml [interquartile range (IQR) 356–984]) than in nonconverters (median 371 pg/ml [IQR 263–578]; P = 0.005). In contrast, C‐reactive protein (CRP) levels were not significantly different between converters and nonconverters at baseline. CXCL10 was associated with conversion status after adjustment for age, sex, duration of psoriasis, and duration of follow‐up (odds ratio 1.3, 95% confidence interval 1.1–1.5, P = 0.004). In a subset of converters, the CXCL10 level was significantly higher at baseline (median 927.4 pg/ml [IQR 547.6–1,243]) than after PsA diagnosis (491.5 pg/ml [IQR 323.2–607]; P < 0.0001), while CRP levels were lower at baseline (26.6 μg/ml [IQR 16.37–62.75]) than after PsA diagnosis (36.1 μg/ml [IQR 14.74–101.7]; P = 0.003). CXCL10 gene expression was increased 17.3‐fold in synovial fluid (SF) compared with blood from PsA patients ( P = 0.01) and 44.3‐fold in the SF of PsA patients compared with the SF of patients with gout ( P = 0.001). Conclusion CXCL10 may be involved in PsA pathogenesis and is a candidate predictive biomarker for PsA in patients with psoriasis.
科研通智能强力驱动
Strongly Powered by AbleSci AI