活性氧
机制(生物学)
分子
氧化磷酸化
材料科学
氧化损伤
纳米技术
作用机理
氧化应激
生物物理学
细胞生物学
化学
生物化学
生物
体外
有机化学
认识论
哲学
作者
Christos Tapeinos,Abhay Pandit
标识
DOI:10.1002/adma.201505376
摘要
Reactive oxygen species (ROS) (H 2 O 2 , OCl − , • OH, O 2 − ) are a family of reactive molecules that are generated intracellularly and are engaged in many biological processes. In physiological concentrations, ROS act as signaling molecules to a number of metabolic pathways; however, in excess they can be harmful to living organisms. Overproduction of ROS has been related to many pathophysiological conditions and a number of studies have been reported in elucidating their mechanism in these conditions. With the aim of harnessing this role, a number of imaging tools and therapeutic compounds have been developed. Here these imaging and therapeutic tools are reviewed and particularly those structures with ROS‐sensitivity based on their biomedical applications and their functional groups. There is also a brief discussion about the method of preparation as well as the mechanism of action.
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