共价键
催化作用
化学
群(周期表)
Atom(片上系统)
联动装置(软件)
分子
基质(水族馆)
组合化学
纳米技术
立体化学
材料科学
有机化学
计算机科学
基因
海洋学
地质学
嵌入式系统
生物化学
作者
A. N. Dey,Sucharita Sinha,Tapas Kumar Achar,Debabrata Maiti
标识
DOI:10.1002/anie.201812116
摘要
Directing group assisted ortho-C-H activation has been known for the last few decades. In contrast, extending the same approach to achieve activation of the distal meta- and para-C-H bonds in aromatic molecules remained elusive for a long time. The main challenge is the conception of a macrocyclic transition state, which is needed to anchor the metal catalyst close to the target bond. Judicious modification of the chain length, the tether linkage, and the nature of the catalyst-coordinating donor atom has led to a number of successful studies in the last few years. This Review compiles the significant achievements made in this field of both meta- and para-selectivity using covalently attached directing groups, which are systematically classified on the basis of their mode of covalent attachment to the substrate as well as their chemical nature. This Review aims to create a more heuristic approach for recognizing the suitability of the directing groups for use in future organic transformations.
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