细胞凋亡
谷胱甘肽
DNA断裂
碎片(计算)
体外
癌症研究
癌细胞
细胞培养
分子生物学
生物
活力测定
化学
程序性细胞死亡
癌症
生物化学
酶
遗传学
生态学
作者
B. Donnerstag,G Ohlenschläger,Jindrich Cinatl,Michael Amrani,Dieter Hofmann,Sven Flindt,Gernot Treusch,Lothar Träger
出处
期刊:Cancer Letters
[Elsevier]
日期:1996-12-01
卷期号:110 (1-2): 63-70
被引量:21
标识
DOI:10.1016/s0304-3835(96)04461-8
摘要
The effect of reduced glutathione (GSH) and S-acetylglutathione (S-acglu) treatment on several tumor cell lines and normal cells in vitro was investigated. GSH and S-acglu applied at concentrations of 1 mM and 2 mM induced apoptosis in malignant cells as shown by DNA-fragmentation and staining of apoptotic cells with 7-amino-actinomycin D while viability and growth of normal cells were not significantly influenced by this treatment. The results demonstrated that GSH and S-acglu may be selective inducers of apoptosis in malignant cells.
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