检出限
化学
线性范围
生物传感器
纳米颗粒
分析化学(期刊)
猝灭(荧光)
胶体金
电极
免疫分析
分析物
材料科学
安培法
硫堇
作者
Qian Cheng,Jinhui Feng,Tingting Wu,Guo Yujian,Xu Sun,Xiang Ren,Jin Yong Lee,Lei Liu,Qin Wei
出处
期刊:Talanta
[Elsevier]
日期:2021-05-27
卷期号:233: 122552-122552
被引量:1
标识
DOI:10.1016/j.talanta.2021.122552
摘要
Abstract In this work, a fire-new “signal-off” type photoelectrochemical (PEC) immunosensor based on bismuth sulfide/iodine doped bismuth oxychloride (Bi2S3/I:BiOCl) heterostructure as a platform and Au nanoparticles loaded hollow CoSnO3 nanoboxes (Au NPs@CoSnO3) as quenching label was designed, for sensitive detection of CYFRA 21-1. The I:BiOCl with flower-like structure could supply high specific surface area for loading nanometer materials. Then, Bi2S3 was formed in-situ by S2− adsorption on the surface of I:BiOCl by dangling bond of Bi3+, but did not change the flower-like structure of I:BiOCl. Then, n-type Bi2S3 and p-type I:BiOCl heterostructure showed good photoelectric behavior by providing an additional electric field to accelerate electron-hole separation. Furthermore, the production process of the heterostructure was simple, fast, low temperature, and without complex raw materials. The Au NPs@CoSnO3 with good photocatalytic activity could strongly compete with Bi2S3/I:BiOCl for electron donor of ascorbic acid (AA). Meanwhile, the CoSnO3 with hollow structure made the quenching effect more significant by the light-scattering effect that enhanced the light absorption capacity and shorten distance of carrier transport. Under optimal conditions, this proposed strategy displayed the low detection limit of 30 fg/mL, with a high linearity range from 100 fg/mL to 100 ng/mL for tumor markers CYFRA 21-1. Simultaneously, it also exhibited excellent specificity and acceptable stability, which might provide a new perspective for the fabrication of other PEC immunosensors with heterostructure simple synthesis and hollow materials.
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