感觉系统
嗅觉系统
嗅球
神经科学
气味
嗅觉
神经活动
生物神经网络
电生理学
嗅上皮
感知
生物
计算机科学
中枢神经系统
作者
Yan Duan,Suhao Wang,Qunchen Yuan,Yingqian Shi,Nan Jiang,Deming Jiang,Jizhou Song,Ping Wang,Liujing Zhuang
出处
期刊:Small
[Wiley]
日期:2023-04-10
卷期号:19 (29)
被引量:1
标识
DOI:10.1002/smll.202205768
摘要
Abstract Humans perceive the world through five senses, of which olfaction is the oldest evolutionary sense that enables the detection of chemicals in the external environment. Recent progress in bioinspired electronics has boosted the development of artificial sensory systems. Here, a biohybrid olfactory system is proposed by integrating living mammals with implantable flexible neural electrodes, to employ the outstanding properties of mammalian olfactory system. In olfactory perception, the peripheral organ—olfactory epithelium (OE) projects axons into the olfactory relay station—olfactory bulb (OB). The olfactory information encoded in the neural activity is recorded from both OE and OB simultaneously using flexible neural electrodes. Results reveal that spontaneous slow oscillations (<12 Hz) in both OE and OB closely follow respiration. This respiration‐locked rhythm modulates the amplitude of fast oscillations (>20 Hz), which are associated with odor perception. Further, by extracting the characteristics of odor‐evoked oscillatory signals, responses of different odors are identified and classified with 80% accuracy. This study demonstrates for the first time that the flexible electrode enables chronic stable electrophysiological recordings of the peripheral and central olfactory system in vivo. Overall, the method provides a novel neural interface for olfactory biosensing and cognitive processing.
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