化学
催化作用
钯
芳基
组合化学
功能群
烷基
有机化学
聚合物
作者
Ya Li,Dian Dong,Lintong Chen,Hai Du,Cong Zhao,Xiaoyin Bai,Lu Chen,Yibiao Li,Xianghua Zeng,Pierre H. Dixneuf,Min Zhang
标识
DOI:10.1021/acs.orglett.3c04191
摘要
The trifluoromethylacyl group (−COCF3) is an important motif and widely studied in catalysis, medicinal chemistry, and materials science. Herein, a novel palladium-catalyzed selenofluoroalkylacylation of terminal alkynes with commercially available fluoroalkyl anhydride and diorganyl diselenides to afford β-seleno and aryl/alkyl disubstituted enones under mild conditions is disclosed. In addition, selenodifluoroacetylations and selenoperfluoroacetylations are also suitable for this reaction. Mechanistic studies reveal that this reaction proceeds via an oxidative radical-polar crossover process.
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