斑马鱼
后代
多巴胺能
达尼奥
平衡
生物
内分泌学
细胞生物学
内科学
多巴胺
生物化学
遗传学
怀孕
医学
基因
作者
Luyin Wu,Mohammed Zeeshan,Yao Dang,Yunting Zhang,Li-Xia Liang,Jiefu Huang,Jiaxin Zhou,Linna Guo,Fan Yang,Mingliang Sun,Yu Chen,Yan Wen,Lizi Lin,Ru-Qing Liu,Guang‐Hui Dong,Chu Chu
标识
DOI:10.1016/j.scitotenv.2023.164838
摘要
Maternal exposure to environment toxicants is an important risk factor for neurobehavioral health in their offspring. In our study, we investigated the impact of maternal exposure to chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs, commercial name: F-53B) on behavioral changes and the potential mechanism in the offspring larvae of zebrafish. Adult zebrafish exposed to Cl-PFESAs (0, 0.2, 2, 20 and 200 μg/L) for 21 days were subsequently mated their embryos were cultured for 5 days. Higher concentrations of Cl-PFESAs in zebrafish embryos were observed, along with, reduced swimming speed and distance travelled in the offspring larvae. Molecular docking analysis revealed that Cl-PFESAs can form hydrogen bonds with brain-derived neurotropic factor (BDNF), protein kinase C, alpha, (PKCα), Ca2+-ATPase and Na, K - ATPase. Molecular and biochemical studies evidenced Cl-PFESAs induce dopaminergic dysfunction, eye developmental defects and disrupted Ca2+ homeostasis. Together, our results showed that maternal exposure to Cl-PFESAs lead to behavioral alteration in offspring mediated by disruption in Ca2+ homeostasis, dopaminergic dysfunction and eye developmental defects.
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