Single-Cell Multi-Omics Identifies Specialized Cytotoxic and Migratory CD8 + Effector T Cells in Acute Myocarditis

Our study provides a comprehensive immune landscape for understanding the pathogenesis of AM, especially in FM, highlighting clonal CD57⁺CD8⁺ effector T cells with high cytotoxicity and migration potential, along with their upstream inflammatory signals, as potential therapeutic targets for mitigating immune-related cardiac damage in AM management, especially in FM.