药物发现
背景(考古学)
神经科学
生物
催交
神经药理学
计算生物学
广谱
计算机科学
生物信息学
组合化学
工程类
古生物学
化学
系统工程
作者
Stefano Romussi,Sebastián Giunti,Natalia Denise Andersen,Maria Jose de Rosa
标识
DOI:10.1080/17460441.2024.2329103
摘要
Human neurodevelopmental and neurodegenerative diseases (NDevDs and NDegDs, respectively) encompass a broad spectrum of disorders affecting the nervous system with an increasing incidence. In this context, the nematode C. elegans, has emerged as a benchmark model for biological research, especially in the field of neuroscience.The authors highlight the numerous advantages of this tiny worm as a model for exploring nervous system pathologies and as a platform for drug discovery. There is a particular focus given to describing the existing models of C.elegans for the study of NDevDs and NDegDs. Specifically, the authors underscore their strong applicability in preclinical drug development. Furthermore, they place particular emphasis on detailing the common techniques employed to explore the nervous system in both healthy and diseased states.Drug discovery constitutes a long and expensive process. The incorporation of invertebrate models, such as C.elegans, stands as an exemplary strategy for mitigating costs and expediting timelines. The utilization of C.elegans as a platform to replicate nervous system pathologies and conduct high-throughput automated assays in the initial phases of drug discovery is pivotal for rendering therapeutic options more attainable and cost-effective.
科研通智能强力驱动
Strongly Powered by AbleSci AI