Canadian Association of Neuropathologists - Abstracts

Primary leptomeningeal lymphoma is a rare disease in the pediatric population.We herein report a case of a ten-year-old boy with primary leptomeningeal lymphoma of precursor B cell type.The boy presented initially with recurrent headache and vomiting that progressed to right sided ptosis, drooping of the left side of the mouth, slurred speech, and tingling and numbness of face and hands.MRI with contrast and CT scan revealed enhancement of the 3 rd , 7 th , and 8 th nerves bilaterally.CSF examination disclosed increased white cell count with predominantly mononuclear cells.The mononuclear cells appeared atypical.CSF flow cytometry confirmed the diagnosis of precursor B cell lymphoblastic lymphoma.Bone marrow examination did not reveal any blast cells.No disease was identified in the solid organs or lymph nodes.To our knowledge this is the first case of primary leptomeningeal precursor B-cell lymphoma without any other organ involvement.