化学
药代动力学
色谱法
尿
体内
粪便
新陈代谢
代谢物
口服
人参皂甙
排泄
质谱法
液相色谱-质谱法
串联质谱法
药理学
人参
电喷雾电离
生物化学
医学
古生物学
替代医学
生物技术
病理
生物
作者
Tianxiu Qian,Zongwei Cai,Ricky N S Wong,Zhi Hong Jiang
摘要
Abstract In vivo metabolism and pharmacokinetic studies on rat were conducted for ginsenoside Rh2, one of the components from ginseng that shows promise of anticancer activity. Liquid chromatography/mass spectrometry (LC/MS) and tandem mass spectrometry (MS/MS) with electrospray ionization were used to determine Rh2 and its metabolites in rat plasma, urine and feces. An average half‐life of 16 min in plasma was obtained after intravenous administration to male Sprague‐Dawley rats at 5 mg/kg. No Rh2 was detected in plasma samples collected from 0 to 24 h following oral administration at 100 mg/kg, and only 0.12–0.25% of the dosed amount was found in the feces samples collected from 0 to 48 h after oral administration at 100 mg/kg. Three metabolites of Rh2 were detected in the feces samples. Oxygenation and deglycosylation were found to be the major metabolic pathways of Rh2. Intense metabolism, rather than excretion, appears to be the reason for the fast clearance of this ginsenoside. Copyright © 2005 John Wiley & Sons, Ltd.
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