Natural Hydrazone Derivatives: Their Sources, Structures, and Bioactivities

Abstract: Hydrazone-containing compounds are a diverse group of bioactive compounds known for their unique chemical features and diverse biological activities. Natural hydrazone derivatives have been identified from various natural sources, including bacteria, plants, fungi, and marine organisms. This work provides a comprehensive review of published works on natural hydrazone derivatives, including their sources, structural features, and biological activity in the period from 1967 to March 2025. In this work, 72 compounds were reviewed, along with 75 references being cited. The reported findings in this work highlight the therapeutic potential of these compounds in pharmaceutical research and drug discovery.