全血细胞减少症
再生障碍性贫血
免疫学
骨髓
发病机制
造血
骨髓衰竭
医学
造血干细胞移植
球蛋白
免疫系统
淋巴细胞
干细胞
移植
生物
内科学
遗传学
作者
Qi Lv,Huiqin Zhang,Na Xiao,Chunyan Liu,Zonghong Shao,Huaquan Wang
标识
DOI:10.2174/1381612826666200317131940
摘要
Aplastic anemia (AA) is a bone marrow failure syndrome characterized by pancytopenia. Decreased numbers of hematopoietic stem cells and impaired bone marrow microenvironment caused by abnormal immune function describe the major pathogenesis of AA. Hematopoietic stem cell transplantation and immunesuppressive therapy are the first-line treatments for AA. Porcine anti-lymphocyte globulin (p-ALG) is a new product developed in China. Several studies have shown that p-ALG exhibited good therapeutic effects in AA.
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