Effect of micro ecological preparation on imbalance of intestinal flora in pediatric blood cancer after chemotherapy

Objective To investigate the effect of micro ecological preparation on imbalance of intestinal flora in pediatric blood cancer after chemotherapy. Methods The clinical data of 60 patients with blood cancer were retrospectively analyzed.All patients were divided into the observation group and control group by different trentment methods,30 cases in each group.The control group were received conventional chemotherapy,the observation group were given Lactobacillus triple viable Bifidobacterium piece(two piece once,tid,4 weeks for a course)on the basis of the control group,the intestinal flora(Enterobacteriaceae,Enterococcus,Bifidobacterium,Lactobacillus,Escherichia coli)were detected before and after chemotherapy,made a record of respiratory, urinary,digestive,skin infections after chemotherapy. Results The Bifidobacterium and Lactobacillus of the observation group after treatment were significantly higher than before treatment(t=3.947,3.636,all P 0.05).The Enterobacter,Enterococcus,Bifidobacterium,Lactobacillus,Escherichia coli of the control group were lower after treatment than before treatment(t=3.712,3.641,3.722,3.543,3.616,all P <0.05),the Enterobacter,Enterococcus,Bifidobacterium,Lactobacillus,Escherichia coli of the observation group after treatment were higher than that of the control group(t=3.327,3.641,6.378,7.367,3.364,all P <0.05).The respiratory tract infection,cholecystitis,colitis,urinary tract infections incidence of the observation group were 50.00%,6.67%,16.67%,23.33%,respectively,which were lower than 93.33%,30.00%,63.33%,60.00%of the control group(χ2=13.871,5.455,13.611,8.297,all P<0.05). Conclusion The intestinal flora may be caused for treatment of chemotherapy,which are the importmant reason of various infections after chemotherapy,the Probiotics can reconstruct the ecological balance of the gut,increase the number of probiotics,foster the growth of normal flora,adjust the intestinal flora,reduce the chance of infection,conducive to the successful completion of chemotherapy,which is worthy of clinical application. Key words: Hematologic Neoplasms; Enterobacteriaceae; Child