All‐in‐One Self‐Powered Microneedle Device for Accelerating Infected Diabetic Wound Repair

Abstract Diabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, a novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining the multifunctional microneedle carried tannin@ZnO microparticles (TZ@mMN) with the self‐powered triboelectric nanogenerator (TENG). In addition to the delivery of tannin and Zn 2+ , TZ@mMN also effectively conducts electrical stimulation (ES) to infected diabetic wounds. As a self‐powered device, the TENG can convert biomechanical motion into exogenous ES to accelerate the infected diabetic wound healing. In vitro experiment demonstrated that TZ@mMN shows excellent conductive, high antioxidant ability, and effective antibacterial properties against both Staphylococcus aureus and Escherichia coli (>99% antibacterial rates). Besides, the TZ@mMN‐TENG can effectively promote cell proliferation and migration. In the diabetic rat full‐thickness skin wound model infected with Staphylococcus aureus , the TZ@mMN‐TENG can eliminate bacteria, accelerate epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α and IL‐6 expression), and promote angiogenesis (higher CD31 and VEGF expression) to accelerate infected wound repair. Overall, the TZ@mMN‐TENG provides a promising strategy for clinical application in diabetic wound repair.