关贸总协定3
转录因子
生物
癌症研究
染色质
基因表达
免疫组织化学
乳腺癌
基因
基因表达调控
膀胱癌
癌症
计算生物学
生物信息学
细胞生物学
免疫学
遗传学
作者
Zekai Qiang,Ibrahim Jubber,Kirsty Lloyd,Marcus Cumberbatch,Jon Griffin
标识
DOI:10.1136/jcp-2023-209017
摘要
GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity. During development, GATA3 plays a key role in cell differentiation. Mutations in GATA3 are linked to breast and bladder cancer. GATA3 expression is a feature of the luminal subtype of bladder cancer and has implications for immune status and therapeutic response. It also has clinical relevance in squamous cell carcinomas and soft tissue sarcomas. This paper reviews the structure and function of GATA3, its role in cancer and its use and pitfalls as an immunohistochemical marker.
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