曲酸
酪氨酸酶
黑色素
生物合成
皮肤美白
色素沉着
化学
体外
生物化学
超氧化物
酶
生物
药理学
活性成分
作者
Sangeun Lee,Sang Yoon Choi,Ho-Cheol Kim,Jae Sung Hwang,Byeong Gon Lee,Jian Gao,Sun Yeou Kim
摘要
The current study was carried out to investigate the in vitro effects of an 85% methanol extract of dried Morus alba leaves on melanin biosynthesis, which is closely related to hyperpigmentation. These extracts inhibited the tyrosinase activity that converts dopa to dopachrome in the biosynthetic process of melanin. Mulberroside F (moracin M-6, 3'-di-O-beta-D-glucopyranoside), which was obtained after the bioactivity-guided fractionation of the extracts, showed inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells. This compound also exhibited superoxide scavenging activity that is involved in the protection against auto-oxidation. But its activity was low and was weaker than of kojic acid. These results suggest that mulberroside F isolated from mulberry leaves might be used as a skin whitening agent.
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