化学
组合化学
过渡金属
贝克曼重排
有机化学
雷贝拉唑
催化作用
生物化学
质子抑制剂泵
作者
Qiang Pu,Mosstafa Kazemi,Masoud Mohammadi
出处
期刊:Mini-reviews in Organic Chemistry
[Bentham Science]
日期:2020-05-31
卷期号:17 (4): 423-449
被引量:32
标识
DOI:10.2174/1570193x16666190430154835
摘要
Sulfoxides are key scaffolds in the synthesis of pharmaceutically active molecules. A large number of sulfoxides are indispensable ingredients in the structure of most antibiotics, biological and natural products such as Modafinil, Adrafinil, CRL-40,941 or fladrafinil, Fipronil, Oxydemetonmethyl, Omeprazole, Pantoprazole, Lansoprazole and Rabeprazole. The oxidation of sulfides is the most common and efficient strategy for the preparation of sulfoxides. Recently, many protocols based on using transition metals have been reported for the oxidation of sulfides to the sulfoxides. In this paper, we summarized a nice category of the reported protocols in the literature for the oxidation of sulfides to sulfoxides.
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