化学
区域选择性
脱氢丙氨酸
弗里德尔-克拉夫茨反应
电泳剂
亲电取代
烷基化
组合化学
色氨酸
有机化学
催化作用
氨基酸
生物化学
作者
Silvia Bartolucci,Francesca Bartoccini,Marika Righi,Giovanni Piersanti
出处
期刊:Organic Letters
[American Chemical Society]
日期:2011-12-30
卷期号:14 (2): 600-603
被引量:32
摘要
A facile synthetic approach to the direct preparation of various novel unnatural boronated protected tryptophans using a regio- and chemoselective electrophilic substitution of 4- and 5-boronated indoles with N-protected dehydroalanine is described. The gram-scale synthesis of two free tryptophan boronic acids is also reported.
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