Calcium Hydride‐Based Dressing to Promote Wound Healing

Abstract Wound microenvironment with excess reactive oxygen species (ROS) can significantly inhibit wound healing. Encouraged by hydrogen molecules (H 2 ) with effective ROS scavenging and calcium hydride (CaH 2 ) with sufficient H 2 supply, the authors for the first time employed CaH 2 as a therapeutic H 2 donor and starch as a diluent to construct CaH 2 pulvis dressing for wound healing treatment. It has been found that CaH 2 by generating H 2 exhibited excellent ROS scavenging performance, favorable for preserving the oxidative‐stress‐induced cell death. After being applied onto the skin wound, the CaH 2 pulvis dressing with the unique ROS‐scavenging ability can accelerate skin wound healing in healthy/diabetic mice (small animal models) and Bama mini‐pigs (large animal model). Such CaH 2 dressing can release H 2 to relieve the inflammation levels, decrease the secretion of pro‐inflammatory cytokines, increase the infiltration of inflammation‐suppressive immune cells, and promote the regeneration of new blood vessels and collagens, thereby accelerating wound healing. This work highlighted that the integration of anti‐oxidation and anti‐inflammation functions based on CaH 2 dressing endowed it with a promising possibility for the treatment of inflammatory diseases.