Selective C–N Bond‐Forming Reaction of 2,6‐Dibromopyridine with Amines

Abstract A practical and efficient protocol for the syntheses of 6‐substituted 2‐bromopyridine compounds has been developed by using a selective copper‐catalyzed C–N bond‐forming reaction between 2,6‐dibromopyridine and a range of amines. The major advantage of this protocol is the complete control of selectivity of the pyridine bromine atom for the C–N cross‐coupling reaction. There are few reported syntheses of unsymmetrical 2,6‐disubstituted pyridine‐bridged compounds because of their complicated preparations. Although this is the case, a new series of these unsymmetrical compounds have been successfully prepared in two steps by using this copper‐catalyzed coupling approach.