葡聚糖
发病机制
肽序列
胍
氨基酸
醋酸
淀粉样蛋白(真菌学)
凝胶渗透色谱法
淀粉样前体蛋白
生物化学
化学
蛋白质一级结构
同源(生物学)
纤维
淀粉样变性
老年斑
阿尔茨海默病
淀粉样β
色谱法
医学
脑淀粉样血管病
β淀粉样蛋白
痴呆
肽
生物
蛋白质聚集
β淀粉样蛋白
血清淀粉样蛋白A
作者
George G. Glenner,Caine W. Wong
标识
DOI:10.1016/s0006-291x(84)80190-4
摘要
A purified protein derived from the twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated by Sephadex G-100 column chromatography with 5 M guanidine-HC1 in 1 N acetic acid and by high performance liquid chromatography. Amino acid sequence analysis and a computer search reveals this protein to have no homology with any protein sequenced thus far. This protein may be derived from a unique serum precursor which may provide a diagnostic test for Alzheimer's disease and a means to understand its pathogenesis.
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