OCIAD2-IQGAP1 interaction promotes pancreatic cancer progression by suppressing oxidative stress and mitochondria-mediated apoptosis

OCIAD2 drives PDAC progression through binding to IQGAP1, which activates PI3K/AKT pathway; this in turn preserves mitochondrial function and suppresses apoptosis. Our study identifies OCIAD2 as a critical mediator of tumor progression and a potential therapeutic target in PDAC.