Ferrocenephosphonates: copper-promoted synthesis and further functionalization

Ferrocenephosphonates are an important class of organometallic derivatives with a wide range of useful applications in organic synthesis and coordination chemistry. Here, an approach to ferrocenephosphonates based on a copper-promoted Hirao coupling is reported. Further functionalization based on regioselective deprotolithiation and both Negishi and Suzuki-Miyaura cross-coupling reactions is also described to reach original derivatives.