新生
免疫系统
生发中心
趋化因子
免疫疗法
生物
癌症研究
淋巴系统
获得性免疫系统
癌症
炎症
抗原
癌症免疫疗法
抗体
免疫学
B细胞
小岛
内分泌学
胰岛素
遗传学
作者
Wolf‐Herman Fridman,Florent Petitprez,Julien Caldéraro,Wolf‐Herman Fridman
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2019-05-15
卷期号:19 (6): 307-325
被引量:916
标识
DOI:10.1038/s41568-019-0144-6
摘要
Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-lymphoid tissues at sites of chronic inflammation including tumours. Key common characteristics between secondary lymphoid organogenesis and TLS neogenesis have been identified. TLSs exist under different maturation states in tumours, culminating in germinal centre formation. The mechanisms that underlie the role of TLSs in the adaptive antitumour immune response are being deciphered. The description of the correlation between TLS presence and clinical benefit in patients with cancer, suggesting that TLSs could be a prognostic and predictive factor, has drawn strong interest into investigating the role of TLSs in tumours. A current major challenge is to exploit TLSs to promote lymphocyte infiltration, activation by tumour antigens and differentiation to increase the antitumour immune response. Several approaches are being developed using chemokines, cytokines, antibodies, antigen-presenting cells or synthetic scaffolds to induce TLS formation. Strategies aiming to induce TLS neogenesis in immune-low tumours and in immune-high tumours, in this case, in combination with therapeutic agents dampening the inflammatory environment and/or with immune checkpoint inhibitors, represent promising avenues for cancer treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI