Access to 2-Amino Benzylic Thioethers via a Hydrolytic Tandem 1,4 Conjugate Addition Reaction of Benzothiazolium Bromides and N-(2-Chloromethyl)aryl Amides

Organosulfides play an important role in the pharmaceutical field and organic synthesis. Herein, an unusual hydrolytic tandem 1,4 conjugate addition reaction between benzothiazolium bromides and N-(2-chloromethyl) aryl amides has been revealed for efficient and convenient preparation of functionalized thioethers. This strategy provides various functionalized thioethers in moderate to excellent yields under mild conditions.