药品
抗药性
抗真菌
抗真菌药
抗真菌药
药理学
药物输送
医学
生物
化学
微生物学
有机化学
作者
Ping Zhu,Yan Li,Ting Guo,Simei Liu,Robert J. Tancer,Changhua Hu,Chengzhi Zhao,Chaoyang Xue,Guojian Liao
标识
DOI:10.1016/j.addr.2023.114874
摘要
The growing occurrence of invasive fungal infections and the mounting rates of drug resistance constitute a significant menace to human health. Antifungal drug combinations have garnered substantial interest for their potential to improve therapeutic efficacy, reduce drug doses, reverse, or ameliorate drug resistance. A thorough understanding of the molecular mechanisms underlying antifungal drug resistance and drug combination is key to developing new drug combinations. Here we discuss the mechanisms of antifungal drug resistance and elucidate how to discover potent drug combinations to surmount resistance. We also examine the challenges encountered in developing such combinations and discuss prospects, including advanced drug delivery strategies.
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