脂肪变性
医学
山茶
山茶花
脂肪性肝炎
脂质代谢
甘油三酯
血脂谱
促炎细胞因子
脂肪肝
食品科学
胆固醇
内科学
内分泌学
生物
植物
炎症
疾病
作者
Katsuhisa Omagari,Kazuhito Suruga,Akira Kyogoku,Satomi Nakamura,A. Sakamoto,Shinta Nishioka,Mayuko Ichimura,Yuji Miyata,Koichi Tajima,Koichi Tsuneyama,Kazunari Tanaka
出处
期刊:Hepatobiliary surgery and nutrition
[AME Publishing Company]
日期:2018-06-01
卷期号:7 (3): 175-184
被引量:2
标识
DOI:10.21037/hbsn.2017.08.03
摘要
Background: Established treatments for non-alcoholic steatohepatitis (NASH) are few, thus it is imperative to develop novel dietary strategies that can prevent NASH. A fermented mixed tea (FMT) made with Camellia japonica (Japanese camellia) and third- crop green tea leaves by tea-rolling processing was reported to reduce body weight and adipose tissue weight in Sprague-Dawley (SD) rats. Because visceral fat is one of the most important factors for the development of hepatic steatosis, this FMT supplementation can be a candidate dietary strategy for the prevention of NASH. Methods: Nine-week-old male SD rats were fed a high-fat and high-cholesterol (HFC) diets with or without FMT (camellia and third-crop green tea leaves at ratios of 1:5, 1:2 and 1:1) for 9 weeks (n=6–7/ group). Histopathology, serology and expressions of fibrogenetic, proinflammatory, oxidative stress and lipid metabolism-related genes in the liver were evaluated. Results: Histologically, HFC diet with FMT at a ratio of 1:5 dramatically reduced NASH progression (14%) compared to the HFC diet without FMT (100%). FMT at a ratio of 1:5 reduced hepatic steatosis due to the activation of microsomal triglyceride transfer protein, and FMT at a ratio of 1:2 reduced mRNA levels of some proinflammatory, lipid metabolism-related, fibrogenic and oxidative stress marker genes. Conclusions: Our data suggest that FMT at a ratio of 1:5 or 1:2 likely possesses a preventive effect on NASH progression.
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