骨重建
铅(地质)
医学
骨质疏松症
骨矿物
铅中毒
骨组织
生理学
内科学
病理
生物
古生物学
精神科
作者
Ellen K. Silbergeld,John J. Sauk,Martha J. Somerman,Andrew C. Todd,Fiona E. McNeill,Bruce A. Fowler,Anne-Marie Fontaine,J. Van Buren
出处
期刊:PubMed
日期:1993-01-01
卷期号:14 (2-3): 225-36
被引量:47
摘要
The primary site of lead storage is in bone but relatively little attention has focused on this physiological compartment. Recent advances in measurement technology now permit the direct in vivo quantitative measurement of lead in bone, and this measure has great use in clinical and epidemiologic studies. Lead in bone is not a physiological sink, but can be mobilized back into the circulation in response to normal or pathological changes in mineral metabolism. Bone lead may be a significant source of target organ exposure under certain conditions, such as pregnancy, kidney disease, and menopause. Finally, the accumulation of lead in bone cells may have toxic consequences for bone status, and some of the mechanisms by which lead could affect bone mineral metabolism may also play a role in other target organ effects of lead.
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