Synthesis, Docking, In vitro and In silico Investigations of novel Tacrine Derivatives as Acetylcholinesterase inhibitors

To identify a lead for Alzheimer's treatment, novel tacrine derivatives were synthesized. Among them, compound 3c showed strong AChE binding (glide score −11.49 kcal mol −1 , binding energy −75.04 kcal mol −1 ) and potent inhibition of IC 50 = 46.8 nM.