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New approaches for small molecule-induced protein degradation

化学 图书馆学 梅德林 医学 生物化学 生物信息学 生物 计算机科学
作者
Song Wu,Huan Xiao,Qiu Sun
出处
期刊:Future Medicinal Chemistry [Future Science Ltd]
卷期号:13 (5): 439-441 被引量:1
标识
DOI:10.4155/fmc-2020-0343
摘要

Future Medicinal ChemistryVol. 13, No. 5 EditorialNew approaches for small molecule-induced protein degradationSong Wu, Huan Xiao & Qiu SunSong Wu https://orcid.org/0000-0001-5935-221XState Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaSearch for more papers by this author, Huan XiaoState Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaSearch for more papers by this author & Qiu Sun *Author for correspondence: E-mail Address: sunqiu@scu.edu.cnhttps://orcid.org/0000-0001-5122-2226State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaSearch for more papers by this authorPublished Online:13 Jan 2021https://doi.org/10.4155/fmc-2020-0343AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: ATTECAUTACLYTACPROTACprotein degradationReferences1. Chiti F, Dobson CM. Protein misfolding, functional amyloid, and human disease. Annu. Rev. Biochem. 75, 333–366 (2006).Crossref, Medline, CAS, Google Scholar2. Walker LC, Levine H. The cerebral proteopathies: neurodegenerative disorders of protein conformation and assembly. Mol. Neurobiol. 21(1–2), 83–95 (2000).Crossref, Medline, CAS, Google Scholar3. Li Z, Zhu C, Ding Y, Fei Y, Lu B. ATTEC: a potential new approach to target proteinopathies. Autophagy 16(1), 185–187 (2020).Crossref, Medline, CAS, Google Scholar4. Neklesa TK, Tae HS, Schneekloth AR et al. Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins. Nat. Chem. Biol. 7(8), 538–543 (2011).Crossref, Medline, CAS, Google Scholar5. Tae HS, Sundberg TB, Neklesa TK et al. Identification of hydrophobic tags for the degradation of stabilized proteins. ChemBioChem 13(4), 538–541 (2012).Crossref, Medline, CAS, Google Scholar6. Scudellari M. Protein-slaying drugs could be the next blockbuster therapies. Nature 567(7748), 298–300 (2019).Crossref, Medline, CAS, Google Scholar7. Wang Y, Jiang X, Feng F, Liu W, Sun H. Degradation of proteins by PROTACs and other strategies. Acta Pharm. Sin. B 10(2), 207–238 (2020).Crossref, Medline, CAS, Google Scholar8. Zhang L, Riley-Gillis B, Vijay P, Shen Y. Acquired resistance to BET-PROTACs (proteolysis-targeting chimeras) caused by genomic alterations in core components of e3 ligase complexes. Mol. Cancer Ther. 18(7), 1302–1311 (2019).Crossref, Medline, Google Scholar9. Kundu M, Thompson CB. Autophagy: basic principles and relevance to disease. Annu. Rev. Pathol 3, 427–455 (2008).Crossref, Medline, CAS, Google Scholar10. Pillay CS, Elliott E, Dennison C. Endolysosomal proteolysis and its regulation. Biochem. J. 363(Pt 3), 417–429 (2002).Crossref, Medline, CAS, Google Scholar11. Banik SM, Pedram K, Wisnovsky S, Ahn G, Riley NM, Bertozzi CR. Lysosome-targeting chimaeras for degradation of extracellular proteins. Nature 584(7820), 291–297 (2020).Crossref, Medline, CAS, Google Scholar12. Ghosh P, Dahms NM, Kornfeld S. Mannose 6-phosphate receptors: new twists in the tale. Nat. Rev. Mol. Cell Biol. 4(3), 202–213 (2003).Crossref, Medline, CAS, Google Scholar13. Ahn G, Banik S, Miller CL, Riley N, Cochran JR, Bertozzi C. Lysosome targeting chimeras (LYTACs) that engage a liver-specific asialoglycoprotein receptor for targeted protein degradation. doi:10.26434/chemrxiv.12736778.v1 (2020).Crossref, Google Scholar14. Van Regenmortel MH. Antigenicity and immunogenicity of synthetic peptides. Biologicals 29(3–4), 209–213 (2001).Crossref, Medline, CAS, Google Scholar15. Takahashi D, Moriyama J, Nakamura T et al. AUTACs: cargo-specific degraders using selective autophagy. Mol. Cell 76(5), 797–810.e710 (2019).Crossref, Medline, CAS, Google Scholar16. Li Z, Wang C, Wang Z et al. Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds. Nature 575(7781), 203–209 (2019).Crossref, Medline, CAS, Google Scholar17. Walker FO. Huntington’s disease. Lancet 369(9557), 218–228 (2007).Crossref, Medline, CAS, Google Scholar18. Ding Y, Fei Y, Lu B. Emerging new concepts of degrader technologies. Trends Neurosci. 41(7), 464–474 (2020).CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 13, No. 5 Follow us on social media for the latest updates Metrics Downloaded 552 times History Received 7 November 2020 Accepted 23 November 2020 Published online 13 January 2021 Published in print March 2021 Information© 2021 Newlands PressKeywordsATTECAUTACLYTACPROTACprotein degradationFinancial & competing interests disclosureThis work was supported by the National Natural Science Foundation of China (21702141). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download

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