神经发生
神经科学
免疫系统
炎症
心理学
促炎细胞因子
细胞因子
免疫学
生物
作者
Alessandra Borsini,Patricia A. Zunszain,Sandrine Thuret,Carmine M. Pariante
标识
DOI:10.1016/j.tins.2014.12.006
摘要
Neurogenesis is an important process in the regulation of brain function and behaviour, highly active in early development and continuing throughout life. Recent studies have shown that neurogenesis is modulated by inflammatory cytokines in response to an activated immune system. To disentangle the effects of the different cytokines on neurogenesis, here we summarise and discuss in vitro studies on individual cytokines. We show that inflammatory cytokines have both a positive and negative role on proliferation and neuronal differentiation. Hence, this strengthens the notion that inflammation is involved in molecular and cellular mechanisms associated with complex cognitive processes and, therefore, that alterations in brain-immune communication are relevant to the development of neuropsychiatric disorders.
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