黑质
路易体
帕金森病
多巴胺能
病理
壳核
α-突触核蛋白
路易氏体型失智症
共核细胞病
医学
神经科学
生物
多巴胺
疾病
痴呆
作者
Jiayi Li,Elisabet Englund,Håkan Widner,Stig Rehncrona,Anders Björklund,Olle Lindvall,Patrik Brundin
摘要
Abstract We previously reported the occurrence of Lewy bodies in grafted human fetal mesencephalic neurons in two patients with Parkinson's disease. Here, we have used immunohistochemistry and electron microscopy to characterize the development of Lewy bodies in one of these cases. This patient was operated in putamen on both sides at 12 or 16 years before death, respectively. We demonstrate that 2% of the 12‐year‐old and 5% of the 16‐year‐old grafted, presumed dopaminergic neurons contained Lewy bodies immunoreactive for α‐synuclein. Based on morphological analysis, two forms of α‐synuclein‐positive aggregates were distinguished in the grafts, the first a classical and compact Lewy body, the other a loose meshwork aggregate. Lewy bodies in the grafts stained positively for ubiquitin and thioflavin‐S, and contained characteristic α‐synuclein immunoreactive electron dense fibrillar structures on electron microscopy. Our data indicate that Lewy bodies develop gradually in transplanted dopaminergic neurons in a fashion similar to that in dopaminergic neurons in the host substantia nigra. © 2010 Movement Disorder Society
科研通智能强力驱动
Strongly Powered by AbleSci AI