医学
放射治疗
头颈部
科克伦图书馆
梅德林
立体定向放射治疗
放射外科
头颈部癌
肿瘤科
外科
荟萃分析
内科学
政治学
法学
作者
Michael S. Kim,Nauman Malik,Hanbo Chen,Ian Poon,Zain Husain,Antoine Eskander,Gabriel Boldt,Alexander V. Louie,Irene Karam
出处
期刊:Head & neck
[Wiley]
日期:2021-12-19
卷期号:44 (3): 770-782
被引量:3
摘要
Management of locoregionally advanced head and neck cancers (HNCs) remains a challenge. Some groups have attempted to use stereotactic radiotherapy (SBRT) to deliver "boost" treatment following conventional radiotherapy to improve local control (LC) and overall survival (OS), while aiming for acceptable toxicities. Medline, EMBASE, and Cochrane Library databases were queried for SBRT as curative-intent planned boost in HNC after conventional radiotherapy. Individual studies were reviewed from inception until January 2021, extracting patient, treatment, and outcome data. Nine studies met inclusion criteria, representing 454 unique patients treated with curative intent across multiple head and neck sites with conventional radiotherapy. At 3 years, median LC was 92% (90%-98%), and median OS was 80% (75%-91%). Seven treatment-related grade 5 toxicities (1.5%) were reported. Despite acceptable LC and OS rates, there were severe treatment-related late toxicities. As such, SBRT boost should only be used in investigational settings until more data is available.
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