miR-196 acts as a tumor suppressor in osteosarcoma by targeting HOXA9.

. Moreover, we revealed that miR-196 could bind to the 3'-untranslated region (3'-UTR) of homeobox A9 (HOXA9) and inhibit HOXA9 expression in OS cell lines. Furthermore, knockdown the expression of HOXA9 resulted in decreased proliferation and migration which was similar to that observed with miR-196 overexpression in OS cell lines. In summary, miR-196 inhibits proliferation and migration of OS cell lines through regulating HOXA9, which might be a useful target for OS treatment.