Ultrastructure of Articular Cartilage of Experimental Osteoarthritis

A method is described for producing a slowly progressing osteoarthritis-like condition and permitting examination of even the earliest phases of degeneration of the articular cartilage in rabbit knee joints.The method consists of making the joint unstable by surgical procedure; this produces a lesion of the same type as found in human osteoarthritis.Degenerative changes produced was examined photomicrographically and electromicrogr-aphically.