42713 Analysis and Implications of Subject Dropout Rates in Psoriatic Biologic Extension Studies: A Systematic Review

Background: Introduction: Patients from completed Randomized Controlled Trials (RCTs) are often recruited to open label extension studies, providing data on long-term efficacy and safety for several years. The current study presents a systematic review of retention rates in extension studies involving the use of biologic agents in the treatment of psoriasis. As most extension studies are conducted with similar methodology, dropout rates may represent a standardized metric across trials that can be used as a corollary for efficacy and tolerability long-term.