医学
亚临床感染
肺功能测试
肺纤维化
2019年冠状病毒病(COVID-19)
内科学
前瞻性队列研究
队列
纤维化
囊性纤维化
队列研究
疾病
传染病(医学专业)
作者
Claire McGroder,Mary M. Salvatore,Belinda D’Souza,Eric A. Hoffman,Matthew R. Baldwin,Christine Kim Garcia
出处
期刊:Thorax
[BMJ]
日期:2024-03-21
卷期号:79 (5): 472-475
被引量:1
标识
DOI:10.1136/thorax-2023-220370
摘要
We conducted a prospective single-centre cohort study of 104 multi-ethnic severe COVID-19 survivors from the first wave of the pandemic 15 months after hospitalisation. Of those who were assessed at 4 and 15 months, improvement of ground glass opacities correlated with worsened fibrotic reticulations. Despite a high prevalence of fibrotic patterns (64%), pulmonary function, grip strength, 6 min walk distance and frailty normalised. Overall, dyspnoea, cough and exhaustion did not improve and were not correlated with pulmonary function or radiographic fibrosis at 15 months, suggesting non-respiratory aetiologies. Monitoring persistent, and often subclinical, fibrotic interstitial abnormalities will be needed to determine their potential for future progression.
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